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Chronic Mucocutaneous Candidiasis

Skin... Nails... And mucous membranes
Characterized by chronic infections
Chronic Mucocutaneous Candidiasis

Sometimes associated with endocrinopathies
Autosomal ressecive forms
The syndrome have been reported
Chronic Mucocutaneous Candidiasis

The Infection spreads from the perenial
And circumoral areas
Scalp, and face
Usually involving fingernails and toenails

Generalized T-cell dysfunction
Severe intestinal pneumonia
Endocrine dysfunction

Serum antobodies
React with a variety of endocrine tissues
This disorder reflects
A generalized autoimmune porcess

Cutaneous Anaphilaxis

Upon injection of antigen into the skin
A local anaphilactic reaction will occur
A wheal and flare reaction
Allergy to a wide variety of antigens
The local increase in vascular permeability
Use of tracer dyes such as Evans blue dye
The binds of albumin in the blood
Blood vassels exhibit increased permeability

Cutaneous Anaphilaxis
Ahhh - Mechanisms of tissue
Active Cutaneous
Anaphilaxis - Swelling and redness
Passive Cutaneous
Anaphilaxis - Specific types of antibody
Passive Cutaneous
Anaphilaxis - Bluing of the skin


The anaphilatic reactions are mediated
By substances such as histamine
Since they are quickly inativated
By tissues and plasma

Adverse Effects Seen in Immunologically Compromised Hosts

Adverse effects of viral vaccines
Seen in normal hosts
The pathogenesis of which is unclear
But which is thought to have an immunologic basis

Postinfectious or postvaccinal
Encephalomyelitis is the classic example
Of a disease mediated by cell-mediated

These children fail to develope teh rash
Of measles and specific measles
Neutralizine antibody ans subsequently die
Adverse effects of vaccines seen
In normal hosts that appear to be
Related to the nature of the
Antigen or the route of administration